Endocrine Abstracts

Introduction: The clinical significance of subclinical thyroid diseases is debated.Design: To assess the relationship between undiagnosed subclinical hypothyroidism (USH), health indicators (HI) and cardiovascular risk factors (CVRF), this cross-sectional study was conducted in 1100 adults representatives of non-institutionalized Catalan population (44.5% men; mean age: 44.8±15.2 years) in Catalonia (Spain); 40 USH (18 men) and 1060 euthyroid (474 m...

The mechanisms triggering autoimmunity in the Graves-Basedow disease (GBD) are unknown, although the evidence for a genetic predisposition is well established. The thyrotropin receptor (TSHR) is a good candidate gene.Objectives: To identify the main alleles/haplotypes of the TSHR gene, and to analyze the existence of TSHR susceptibility alleles to the GBD.Material and methods: To establish the main alleles of TSHR gene, 54 polymorp...

The impairment of cognitive function found in patients treated for pituitary adenomas has been associated with the effects of conventional radiotherapy (CR). Our aim was to compare the results of an examination of verbal memory function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by CR. We retrospectively compared these two outcome groups and carried out a story recall test that included free ...

Neurocognitive dysfunction has been described in patients following pituitary radiotherapy. However, the relative contributions of other variables such as hormone-deficiency states and surgery is still unknown. Our aim was to compare the results of an examination of executive function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by conventional radiotherapy (CR) using a two-field technique. We ...

Introduction: Pigmented micronodular adrenal dysplasia (PMNAD) is an infrequent cause of Cushing syndrome ACTH-independent, and can form a part of Carney syndrome (CS). In both, regulatory subunit mutations of the protein kinase A (PRKAR1A) have been demonstrated, but without apparent genotype-phenotype correlation.Objective: To demonstrate the mutation of PRKAR1A and its functional and clinical expression in a family affected with PMNAD.<p class="ab...

Diabetes mellitus (DM) is a disease that results from impairment of insulin synthesis/secretion or signaling. The glycemia of type 1 DM (DM1) patients is controlled by insulin replacement therapy, which chronically results in insulin resistance. We have shown that alloxan-induced diabetic rats present hypothyroidism, and that T3 treatment reduced the inflammatory state and hepatic glucose production and increased insulin sensitivity, improving glycemia control. Considering tha...

The skeletal muscle expresses the Glucagon-like Peptide 1 (GLP-1) receptor, although its effects in this tissue are not well known. Muscles are a major sink of energy substrates. The aim of our study was to examine the mid-term effect of Liraglutide (LIRA), a GLP-1 receptor agonist, in the expression of molecular indicators of the metabolic activity of the muscle, which includes enzymes, transporters, and intracellular signals. Twenty young Spague-Dawley male rats (350-400 g) ...

Introduction: Knowing mental representations about the phenomenon of illness and medical care allows the clinical team to have better emotional handling of their patients, with gains in greater adherence to treatments. Graves’ Ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and orbit, being the most frequent extrathyroidal manifestation of Graves’ disease (GD). Many patients have psychological status changes even after su...

Introduction: Bilateral macronodular adrenal disease (BMAD, former PBMAH) is a rare cause of Cushing’s syndrome. The few morphologic descriptions of BMAD mention multinodular hyperplastic adrenal glands composed of clear spongiocytic cells and fewer compact eosinophilic cells without any morphologic variation. The discovery of ARMC5 and KDM1A mutations argues for genetic heterogeneity. The aim of this work was to describe the morphological and immunohist...

Introduction: Bilateral macronodular adrenocortical disease (BMAD) is an adrenal cause of Cushing’s syndrome explained in a subset of patients by inactivation of the tumor suppressor genes ARMC5 or KDM1A. Genetic and transcriptomic studies cluster BMAD in 3 distinct molecular groups: one with ARMC5 inactivation, one with KDM1A inactivation and a third group with no known genetic cause. Although ARMC5 and KDM1A are invo...